3-CHYMOTRYPSIN-LIKE PROTEASE (3CLPRO) OF SARS-COV-2: VALIDATION AS A MOLECULAR TARGET, PROPOSAL OF A NOVEL CATALYTIC MECHANISM, AND INHIBITORS IN PRECLINICAL AND CLINICAL TRIALS

Proteases represent common targets in combating infectious diseases, including COVID-19.The 3-chymotrypsin-like protease (3CLpro) is a validated molecular target for COVID-19, and it is key for developing potent and selective inhibitors for inhibiting viral replication of deroyal finger spring SARS-CoV-2.In this review, we discuss structural relati

In this study, we propose a tightly coupled integrated method of ultrawideband (UWB) and light detection and ranging (LiDAR)-based simultaneous localization and mapping (SLAM) for global navigation satellite system (GNSS)-denied environments to achieve high-precision positioning with reduced drift.Specifically, we focus on non-line-of-sight (NLOS)

Cultural heritage represents the link between past and present civilizations, contributing to the right appreciation of the present-day by understanding the historical evolution of different human communities that are shaping our world.Preservation of the cultural heritage and mitigating potential risks on invaluable artifacts or objectives is key

Immersive technologies are revolutionary technological advancements that offer users unparalleled experiences of immersion in a virtual or mixed world of virtual and real elements.In such technology, user privacy, security, and anonymity are paramount, as users often share private and sensitive information.Therefore, user authentication is a critic